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There is none of the many cleaners that has a 100% safety guarantee when it comes to avoiding deletion of files by accident which are vital to the operating system.
This is the reason why you must have a backup registry so you can recover anything if you mistakenly delete something.

Requisite No. 2: Can These Windows XP Registry Cleaners Find, And Fix, All The Known Problems That Plague Registries?

There are a variety of different issues that can pop up within the registry. A Window XP software registry cleaner must obtain comprehensive databases that will cover all, if not most of these dangers.